Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?
نویسندگان
چکیده
منابع مشابه
Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ) in human sperm?
Socio-economic factors have led to an increasing trend for couples to delay parenthood. However, advancing age exerts detrimental effects upon gametes which can have serious consequences upon embryo viability. While such effects are well documented for the oocyte, relatively little is known with regard to the sperm. One fundamental role of sperm is to activate the oocyte at fertilisation, a pro...
متن کاملA maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
BACKGROUND Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of male infertility are caused by failure of the sperm to activate the oocyte, a process normally regulated by calcium oscillations, thought to be induced by a sperm-specific phospholipase C, PLCzeta (PLCζ). Prev...
متن کاملLoss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
BACKGROUND Mammalian oocyte activation occurs via a series of intracellular calcium (Ca(2+)) oscillations thought to be induced by a sperm-specific phospholipase C zeta (PLCζ). There is now strong evidence to indicate that certain types of human male infertility are caused by failure of the sperm to activate the oocyte in an appropriate manner. Molecular analysis of the PLCζ gene of a male pati...
متن کاملPhospholipase C zeta parameters in sperm from polymorphic teratozoospermic men.
Teratozoospermia is a disorder associated with high abnormal sperm morphology which affects fertility in males. In recent years, it has been described that biomarker-based sperm quality evaluation can alleviate male infertility treatment. Phospholipase C zeta (PLCζ) is a sperm-specific factor which appears to be a predicting biomarker for fertilization potential of males. Following fertilizatio...
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چکیده هدف اصلی تحقیق حاضر مطالعه و بررسی رابطه بین خودکارامدی شنیداری با درک شنیداری بود.همچنین رابطه درک شنیداری وخودکارآمدی شنیداری با جنسیت و رابطه خودکارامدی شنیداری با سن نیز مورد بررسی قرار گرفت.تعداد شصت زبان اموز-سی دختر و سی پسر- کانون زبان ایران در مرکز خرم آباد به صورت تصادفی انتخاب شدند. روشهای به کار رفته در جمع اوری داده ها عبارت بودند ازبرسشنامه خودکارآمدی و تست درک شنیداری لانگ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep27543